Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance
نویسندگان
چکیده
منابع مشابه
Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance.
Autoimmune responses to meiotic germ cell antigens (MGCA) that are expressed on sperm and testis occur in human infertility and after vasectomy. Many MGCA are also expressed as cancer/testis antigens (CTA) in human cancers, but the tolerance status of MGCA has not been investigated. MGCA are considered to be uniformly immunogenic and nontolerogenic, and the prevailing view posits that MGCA are ...
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BACKGROUND Prescription of antioxidants might increase the quality of sperm parameters and improve the rate of pregnancy in obese people who suffer from infertility. Therefore, the present study investigated protective effects of vitamin A, E and astaxanthin on sperm parameters and seminiferous tubules epithelium in high-fat diet model. METHODS Thirty-six numbers of 3 months old albino Wistar...
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Background This study aimed to investigate whether Artificial Seminiferous Tubules (AST) coated with testicular extra cellular matrix (ECM) support maturation of spermatogenic cells from immature testes. MaterialsAndMethods Medical grade tubes coated with testicular ECM were used. Testes from immature mice were loaded in the concentration of 10000- 20000/ml. Tubes were then immersed in germ cel...
متن کاملprotective effects of antioxidants on sperm parameters and seminiferous tubules epithelium in high fat-fed rats
background: prescription of antioxidants might increase the quality of sperm parameters and improve the rate of pregnancy in obese people who suffer from infertility. therefore, the present study investigated protective effects of vitamin a, e and astaxanthin on sperm parameters and seminiferous tubules epithelium in high-fat diet model. methods: thirty-six numbers of 3 months old albino wistar...
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At the Cleveland meeting of the American Association of Anatomists, (1912-1913), Curtis1 reported on wax plate reconstructions of the seminiferous tubules of the white mouse, presenting figures of a model of an entire tubule having an actual length of somewhat over 13 em. The tubule completely reconstructed presents the form of an arch, the two ends of the arch lying in close proximity, each te...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2017
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci89927